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- 29th century BC (2900–2801 BC) 29th century BC
- 2AM (South Korean ballad group) 2AM
- Two-dimensional (2D) shapes and concepts 2D
- 2DTV: British Satirical Animated Series (2001–2004) 2DTV
- 2G (second-generation mobile phone technology) 2G
- 2nd century (101–200 AD) 2nd century
- 2nd century BC (200–101 BC) 2nd century BC
- Second Millennium (1001–2000) 2nd millennium
- 2nd millennium BC (c. 2000–1001 BC) 2nd millennium BC
- 2NE1 — South Korean K-pop girl group (2009–2016) 2NE1
- 2Pacalypse Now (debut album by Tupac Shakur) 2Pacalypse Now
- 2PM (South Korean boy band) 2PM
- Year 3 (AD 3) 3
- 3 (Britney Spears song)
- Three (3): mathematical properties, history, and cultural significance 3 (number)
- 3 BC
- 3 Doors Down
- 3 Juno (asteroid) 3 Juno
- 3 Maccabees
- 3 Musketeers (chocolate bar)
- 3 World Trade Center (175 Greenwich Street) — overview, design, and significance 3 World Trade Center
- 3. Liga — Third Division of German Football 3. Liga
- AD 30 — the year in the 1st century 30
- 30 (number)
- 30 BC — Fall of the Ptolemaic Kingdom and Octavian's Rise 30 BC
- 30 de Febrero — Ha*Ash (studio album) 30 de Febrero
- 30 Minutes or Less (2011 film) 30 Minutes or Less
- 30 Rock (American television sitcom) 30 Rock
- 30 Seconds to Mars
- 300 (comics)
- 300 North LaSalle — Chicago office skyscraper 300 North LaSalle
- 301 (number, HTTP status code, year, and other uses) 301
- 302 BC
- Year 303 (AD) — overview and historical significance 303
- The 30s (AD 30–39): a concise historical overview 30s
- 30th Street Station, Philadelphia — major rail hub on the Northeast Corridor 30th Street Station
- Year 31 (AD 31) 31
- 31 BC
- 310 BC
- 311 (common year of the Julian calendar) 311
- 311 South Wacker Drive, Chicago skyscraper 311 South Wacker Drive
- 312
- Year 313 (AD): Edict of Milan and developments in the late Roman world 313
- 314 (number and year) 314
- Year 32 (AD 32) 32
- 32 BC (Year of the Consulship of Ahenobarbus and Sosius) 32 BC
- 32 Fouettés en Tournant
- 32-bit computing
- Year 320 (CCCXX) — overview and historical context 320
- 3200 Phaethon: an asteroid-like body and parent of the Geminid meteors 3200 Phaethon
- 321 BC — Key events in the Hellenistic successor struggles and the Roman Republic 321 BC
- 323 — the number and the years 323 BC and AD 323 323
- 324 (AD) 324
- 324 Bamberga — large, high‑eccentricity main‑belt asteroid 324 Bamberga
- 325 (AD) — Council of Nicaea and developments in Late Antiquity 325
- Sega 32X — 32‑bit add‑on for the Mega Drive/Genesis 32X
- Year 33 (AD 33) 33
- 33 BC — a year in the late Roman Republic 33 BC
- Year 330 (AD): Foundation of Constantinople and the Late Roman World 330
- 331 BC
- Year 333 (AD) — an overview of the mid-4th century calendar year 333
- Year 334 (AD) — Roman-era overview and global context 334
- Year 336 (CCCXXXVI) — a leap year of the Julian calendar 336
- 336 BC — Assassination of Philip II and Accession of Alexander 336 BC
- 337 (AD) — Death of Constantine and the Division of the Roman Empire 337
- Year 339 (CCCXXXIX) — Late Antiquity context and developments 339
- Year 34 (AD 34) 34
- Thirty-four (number) 34 (number)
- 34 BC
- 340s (AD 340–349) 340s
- Year 349 (CCCLXLIX) — a year in Late Antiquity 349
- 34th Annie Awards (2007) — Honoring 2006 Animation 34th Annie Awards
- 34th G8 Summit — Tōyako (Toyako), Japan, July 2008 34th G8 summit
- Year 35 (AD 35) — calendar year of the Roman Empire 35
- 35 BC — a year in the late Roman Republic 35 BC
- Year 350 (Common year of the Julian calendar) 350
- 350 BC
- 350s (decade): civil war in Rome, Julian's campaigns, and Christian councils 350s
- 358 BC
- Year 36 (AD 36) 36
- 36 (number) — mathematical properties, history, and uses 36 (number)
- 36 BC — Roman events, calendar notes, and historical context 36 BC
- 360 (year) — Roman politics, calendar details, and historical context 360
- The 360s (AD 360–369): imperial change and religious conflict 360s
- 365 (song)
- AD 37 — death of Tiberius and accession of Caligula 37
- 37 (number)
- 37 BC
- 370 BC
- Year 372 (CCCLXXII) 372
- Year 376 (AD): Gothic migration and Roman crisis 376
- 37th parallel north a circle of latitude that is 37 degrees north of the Earth's equatorial plane
- AD 38 38
- 38 BC
- 380 BC
- The 380s (AD 380–389): Empire, Church, and Eurasian turning points 380s
- 385 BC
- 385571 Otrera — a Neptune Trojan asteroid at Neptune's L4 point 385571 Otrera
- 38th G8 Summit — Camp David, May 2012 38th G8 summit
- AD 39 39
- 39 BC
- 390 BC
- The 390s (AD 390–399) 390s
- Year 391 (Common year in the Julian calendar) 391
- 395 (number) 395
- 397 (number and year) 397
- Three-dimensional (3D): concept, measurement, perception, and applications 3D
- 3D (album) — TLC's final studio album 3D (album)
- 3D printing (additive manufacturing): overview, methods, materials, and uses 3D printing
- 3D television (stereoscopic and glasses-free displays) 3D television
- 3DO Interactive Multiplayer 3DO
- 3G — Third-generation mobile telecommunications 3G
- 3OH!3 — American electronic pop duo from Boulder, Colorado 3OH!3
- 3rd century (201–300 CE): Political upheaval and cultural change 3rd century
- 3rd century BC (300–201 BC): overview, events, and legacy 3rd century BC
- Third Millennium (2001–3000 CE) 3rd millennium
- 3rd millennium BC
- AD 4 (year 4) 4
- 4 (album) — Beyoncé 4 (Beyoncé album)
- Four (number) 4 (number)
- 4 Baruch (Paraleipomena of Jeremiah) 4 Baruch
- 4 BC
- 4 in the Morning (Gwen Stefani song) 4 in the Morning
- 4 Maccabees: Greek treatise on reason, martyrdom, and Hellenistic Jewish ethics 4 Maccabees
- 4 Vesta — a large, bright protoplanet of the main asteroid belt 4 Vesta
- 4 World Trade Center (150 Greenwich Street) 4 World Trade Center
- 4-H (United States youth development organization) 4-H
- 4×4=12 — studio album by deadmau5 4×4=12
- Year 40 (AD 40) 40
- Forty (number) 40 (number)
- 40 BC — Roman politics, calendar ambiguity, and key events 40 BC
- 40 Wall Street — Art Deco skyscraper in Manhattan's Financial District 40 Wall Street
- Year 400 (AD) 400
- 400s (400–409 CE) 400s
- 401 (CDI) — Year in the Julian calendar 401
- 402 (Common Era) 402
- 404 (year) 404
- 405 BC
- 406 BC
- 408 (AD) — leap year, Roman crisis, and the number 408
- 40s: the 1940s and the life stage of one's forties 40s
- 40th Parallel North a circle of latitude that is 40 degrees north of the Earth's equatorial plane
- Year 41 (AD): assassination of Caligula and accession of Claudius 41
- 41 BC — Year of political conflict in the late Roman Republic 41 BC
- The 410s (410–419): Sack of Rome and the Fragmentation of the West 410s
- 411 BC
- 418 (year) 418
- AD 42 (42 CE) 42
- 42 — the fictional 'Answer to the Ultimate Question' and its cultural legacy 42 (answer)
- 42 (2013 film) 42 (movie)
- 42 (number)
- 42 BC — Battle of Philippi and the transformation of Rome 42 BC
- Year 422 (CDXXII) 422
- 427 BC
- 427 Special Operations Aviation Squadron
- Year 428 (CDXXVIII) 428
- 429 BC: Pericles' Death and the Athenian Plague during the Peloponnesian War 429 BC
- AD 43 43
- 43 Ariadne
- 43 BC — Roman Republic: power struggles and the rise of the Second Triumvirate 43 BC
- 430 BC: Peloponnesian War developments and the Athenian plague 430 BC
- 4319 Jackierobinson — Main-belt asteroid honoring Jackie Robinson 4319 Jackierobinson
- 432 Park Avenue
- 433 Eros: A large Near‑Earth asteroid and NEAR Shoemaker target 433 Eros
- AD 44 (year) 44
- 44 (number)
- 44 BC — The Year of Caesar's Assassination and Roman Transition 44 BC
- Year 45 (AD): Roman consuls, Claudius's reign, and global context 45
- 45 (number)
- 45 BC — first year of the Julian calendar 45 BC
- 45 Eugenia
- AD 46 — a year in the 1st century 46
- 46 BC — The Year of the Consulship of Caesar and Lepidus 46 BC
- 463 (number) 463
- 464 BC
- Year 47 (AD) 47
- 47 (number)
- Year 47 BC: Julius Caesar, the Alexandrine campaign, and the Battle of Zela 47 BC
- 470 BC
- 470s (470–479 AD) 470s
- 473 BC
- 476 (AD): Deposition of the last Western Roman emperor 476
- Year 477 (AD 477) 477
- 479 BC — key events and significance 479 BC
- Year 48 (AD) 48
- 48 (number)
- 48 BC — Roman civil war, Battle of Pharsalus and Pompey's flight 48 BC
- 48 Hours (American news magazine and documentary television series) 48 Hours (TV series)
- 48 Hrs. — 1982 action-comedy that helped define the buddy cop film 48 Hrs.
- 480: number, properties and notable uses 480
- 480 BC
- 480i: Standard-definition interlaced video format (NTSC-derived) 480i
- The 480s (AD): a decade of transition in Eurasia and North Africa 480s
- Year 483 (CDLXXXIII) 483
- 486958 Arrokoth
- AD 49 49
- 49 BC: Caesar's Crossing and the Opening of the Roman Civil War 49 BC
- The 490s (AD 490–499) 490s
- 491 (AD): Death of Emperor Zeno and Accession of Anastasius I 491
- 495 BC
- 496 BC
- Year 497 (AD): political and chronological overview 497
- 499 BC — start of the Ionian Revolt and wider ancient context 499 BC
- 4AD — influential British independent record label 4AD
- 4chan: English-language imageboard, community, and cultural influence 4chan
- Four Dimensions (4D): Geometry, History, and Physical Meaning 4D
- Fourth-generation mobile networks — 4G: technology, performance, and rollout 4G
- 4K resolution (Ultra HD): overview, standards, and practical use 4K resolution
- 4Kids Entertainment — history and role in children's television 4Kids
- 4Minute: South Korean K-pop girl group (2009–2016) 4Minute
- 4th century (301–400) 4th century
- 4th century BC (400–301 BC) 4th century BC
- 4th millennium BC
- Year 5 (AD) — Roman year and calendar overview 5
- Five (number) 5 (number)
- 5 August 2018 Lombok earthquake
- 5 BC
- 5 Seconds of Summer: Australian pop-rock band overview 5 Seconds of Summer
- 5 Tracks (EP) — John Cale 5 Tracks
- 5 World Trade Center (130 Liberty Street) 5 World Trade Center
- 5-1-1 — United States and Canadian travel and traffic information number 5-1-1
- AD 50 (L) 50
- 50 (number): properties, history and uses 50 (number)
- 50 BC: A Pivotal Year in the Late Roman Republic 50 BC
- 50 Cent (Curtis Jackson) 50 Cent
- 50 First Dates (2004 film) 50 First Dates
- Year 500 (AD): Calendar, Roman Numeral, and Historical Context 500
- 500 (number)
- 500 Home Run Club (Major League Baseball milestone) 500 home run club
- 500 Series Shinkansen
- 5000 metres (5K): track distance, road races, and competitive context 5000 metres
- 50000 Quaoar — trans-Neptunian object and dwarf‑planet candidate 50000 Quaoar
- 500s (decade AD 500–509) 500s
- Year 501 (Common year in the Julian calendar) 501
- 509 (number and years) 509
- 50PLUS (Netherlands) — political party for older citizens 50PLUS
- The 50s (AD 50–59): Roman politics, early Christianity and global context 50s
- 51 (number)
- 51 BC — a year in the late Roman Republic 51 BC
- 51 Pegasi — Sun-like star and host of the first hot Jupiter around a solar-type star 51 Pegasi
- 51 Pegasi b (Dimidium) — the first hot Jupiter found around a Sun-like star 51 Pegasi b
- 512 (number and year) 512
- 5145 Pholus — a very red Centaur of the outer Solar System 5145 Pholus
- 515 (year) 515
- 51st State: Meaning, Candidates, and Political Context 51st state
- Year 52 (AD 52) 52
- 52 BC: Crisis in Rome and Caesar’s Victory in Gaul 52 BC
- 52 Europa — large main-belt asteroid 52 Europa
- Year 525 (DXXV) 525
- 53 (number)
- 53 BC
- Year 530 (DXXX): overview, events and historical context 530
- Year 532 (AD) 532
- 533 (Common year) — Events and historical significance 533
- 537 (number) 537
- AD 54 54
- 54 (number)
- 540 (number) 540
- The 540s (540–549): Warfare, plague and political change 540s
- Year 547 (Common year of the Julian calendar) 547
- Year 548 (DXLVIII) 548
- Year 549 (DXLIX) 549
- 54th Massachusetts Volunteer Infantry Regiment 54th Massachusetts Infantry Regiment
- Year 555 (AD) 555
- 56 (number and year AD) 56
- 56 (number) — properties, representations, and notable facts 56 (number)
- 571 (year) 571
- Year 578 (AD) 578
- 580s BC
- 585 (number and years 585 BC / AD 585) 585
- 585 BC
- Year 587 (AD) — calendar, context and overview 587
- 588 Achilles — First-discovered Jupiter Trojan asteroid 588 Achilles
- 5G — the fifth generation of cellular mobile networks 5G
- 5th century (401–500 CE) 5th century
- 5th century BC (500–401 BC) — Classical Age and Mediterranean Empires 5th century BC
- 5th G7 Summit (1979) — Tokyo meeting of industrial democracies 5th G7 summit
- AD 6 (Year 6) 6
- Six (number) 6 (number)
- 6 BC
- 6‑plus‑6 instruments: two‑row, whole‑tone/isomorphic keyboard layouts 6-plus-6-instruments
- AD 60 (60 CE) 60
- 60 (number)
- 60 Minutes — CBS news magazine specializing in investigative and in-depth reporting 60 Minutes
- Year 600 (common year) 600
- 601 — the year AD 601 and the number 601
- Year 602 (AD) — Political upheaval and the prelude to wider wars 602
- 609 AD 609
- The 60s: Decades Referred to as the '60s' Across Centuries 60s
- 60s BC (60–51 BC) 60s BC
- 617 Patroclus — a binary Jupiter Trojan 617 Patroclus
- Year 619 (DCXIX) 619
- AD 62 (62 CE) — a year in the 1st century 62
- 622: the number, its properties, and the year AD 622 622
- Year 623 (AD 623) 623
- 624 Hektor — largest Jupiter Trojan and elongated contact‑binary candidate 624 Hektor
- 625 (year) 625
- AD 63 (common year in the 1st century) 63
- 63 Building (63 City) — Seoul skyscraper and cultural complex 63 Building
- 632 (Common Era) 632