Hossein Sheikholeslam (Persian: حسین شیخ‌الاسلام; 29 November 1952 – 5 March 2020) was an Iranian politician, activist and diplomat. He was an advisor to the foreign minister Javad Zarif. He also was a member of the Seventh Islamic Parliament of Iran fro 2004 to 2008. He was the Iranian ambassador to Syria from 1998 to 2003. He was born Isfahan, Iran.

Sheikholeslam was one of the students/militants who held Americans hostage during the Iran hostage crisis.

Sheikholeslam died on 5 March 2020 in Tehran from the novel coronavirus.