Isa bin Salman Al Khalifa, GCB, GCMG (Arabic: عيسى بن سلمان آل خليفة; 3 June 1933 – 6 March 1999) was the 1st emir of Bahrain from 1961 until his death. Born in Jasra, he became emir upon the death of his father, Salman ibn Hamad.

The emir died of a heart attack. He was succeeded by his son, Hamad bin Isa Al Khalifa.