Humberto Maturana (September 14, 1928 – May 6, 2021) was a Chilean biologist and philosopher. He was one of the second-wave systems scientists and cyberneticians. Maturana was born in Santiago, Chile.

Maturana, with Francisco Varela, was known for creating the term autopoiesis about the nature of life. His work has been influential in many fields, mainly the field of systems thinking and cybernetics. Overall, his work is concerned with the biology of cognition.

Maturana died on May 6, 2021 in Santiago from pneumonia at the age of 92.