Glenn O'Brien (March 2, 1947 – April 7, 2017) was an American writer, largely on the subjects of art, music and fashion. He was featured for many years as "The Style Guy" in GQ magazine, and published a book with that title. He was known for being part of The Factory with Andy Warhol.

He has worked as an editor at a number of publications, and published the arts and literature magazine Bald Ego from 2003-2005.

From 1978 to 1982, O'Brien hosted a New York city Public-access television cable TV show called TV Party.

O'Brien died of complications from pneumonia in Manhattan on April 6, 2017 at the age of 70.