The Invincible Province of Santa Fe is a province of Argentina. It is in the center-east of the country. Santa Fe's most important cities are Rosario, the capital Santa Fe, Rafaela, Villa Gobernador Gálvez, Venado Tuerto, Reconquista, and Santo Tomé.
In 1889 the National University of the Littoral was formed.
Cattle are important to the province for both meat and milk.