Keddie is a census-designated place in Plumas County, California, United States. The population was 66 at the 2010 census.

Keddie is located at 40°0′21″N 120°57′25″W / 40.00583°N 120.95694°W / 40.00583; -120.95694 (40.005901, -120.956899).

Keddie was also the site of the Keddie murders, a notorious quadruple homicide.