Horry County (/ˈɒr/ ORR-ee) is a county in the U.S. state of South Carolina. As of the 2010 census, the population was 289,650, making it the fifth-most populous county in South Carolina. The county seat is Conway.

The county is in the Pee Dee region of South Carolina, about 90 miles north of Charleston, South Carolina and about 130 miles east of the state capital, Columbia.