Claypool is a census-designated place (CDP) in Gila County, Arizona, United States. The population was 1,538 at the 2010 census.
Claypool is located in southern Gila County at 33°24′31″N 110°50′51″W / 33.40861°N 110.84750°W (33.408626, -110.847532), between Miami to the west and Globe, the county seat, to the east. U.S. Route 60 runs along the northern edge of the community.