William Fife Knowland (June 26, 1908 – February 23, 1974) was an American politician, newspaper publisher, and Republican Party leader. He was a U.S. Senator representing California from 1945 to 1959. He was Senate Majority Leader from August 1953 to January 1955 after the death of Robert A. Taft. In 1958, he made a failed run for Governor of California.

On February 23, 1974, Knowland shot himself in the head at his summer home near Guerneville, California at the age of 65. He died owing over $900,000 to banks and impatient mobsters.