Borsele, Zeelandic: Bossele, is a municipality on the former island of Zuid-Beveland, Province of Zeeland, the Netherlands.
About 23,000 people were living in Borsele in 2017.
The Western Scheldt is to the south of the municipality.
The north entrance of the Western Scheldt Tunnel is in Borsele.
Borssele Nuclear Power Station is also in the municipality.