Mountain Brook is a city in Jefferson County, Alabama, United States. The city is a suburb of Birmingham, Alabama. In 2005, Mountain Brook had a population of 20,821, and is on several lists of the United States' richest communities.

Mountain Brook was created after an election was held on March 24, 1942, with 263 voting in favor of incorporation and 67 opposing. The area was founded by Robert Jemison, and the city was designed by Warren H. Manning. Mountain Brook was built around three villages: English Village, Mountain Brook Village, and Crestline Village.

Mountain Brook is the hometown of Friends actress Courteney Cox and missing person Natalee Holloway.