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Matthew Gray Gubler (2017)
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Jeanne Tripplehorn (1992)
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Jennifer Love Hewitt (2008)
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The German language dubbing of the series takes place at EuroSync GmbH in Berlin. Dagmar Preuß wrote the dialogue books for the first two seasons. Her successors were Peter Krone (seasons 3 to 9) and Paul Kaiser (from season 10). Preuß also directs the dialogue with Elke Weidemann.
| Roll | Actors | Starring (episode) | Supporting (episode) | Voice actor |
| Supervisory Special Agent Dr. Spencer Reid | Matthew Gray Gubler | 1.01–15.10 | | Nicola Devico Mamone |
| Supervisory special agent aaron "hotch" hotchner | Thomas Gibson | 1.01–12.02 | | Thomas Nero Wolff (Seasons 1-6)Frank Röth (Seasons 7-12) |
| Supervisory Special Agent Derek Morgan | Shemar Moore | 1.01–11.18 | 12.22, 13.05 | Michael Deffert |
| Supervisory Special Agent Jason Gideon | Mandy Patinkin | 1.01–3.02 | | Erich Räuker |
| Supervisory Special Agent Elle Greenaway | Lola Glaudini | 1.01–2.06 | | Sabine Arnhold |
| Supervisory Special Agent Jennifer "JJ" Jareau... | A. J. Cook | 1.02–6.027 .01–15.10 | 6.18, 6.24 | Tanja Geke |
| Technical Analyst Penelope Garcia | Kirsten Vangsness | 2.01–15.10 | 1.01–1.22 | Almut Zydra |
| Supervisory Special Agent Emily Prentiss | Paget Brewster | 2.09–6. 187.01–7. 2412.03–15.10 | 9.14, 11.19 | Ulrike Stürzbecher |
| Supervisory Special Agent David Rossi | Joe Mantegna | 3.06–15.10 | | Jan Spitzer |
| Special Agent Ashley Seaver | Rachel Nichols | 6.15–6.24 | 6.10–6.12 | Debora Weigert |
| Supervisory Special Agent Dr. Alex Blake, née Miller. | Jeanne Tripplehorn | 8.01–9.24 | | Anke Reitzenstein |
| Supervisory Special Agent Kate Callahan | Jennifer Love Hewitt | 10.01–10.23 | | Melanie Hinze |
| Supervisory Special Agent Dr. Tara Lewis | Aisha Tyler | 12.01–15.10 | 11.01–11.22 | Arianne Borbach |
| Supervisory Special Agent Luke Alvez | Adam Rodriguez | 12.01–15.10 | | Florian Halm |
| Supervisory Special Agent Stephen Walker | Damon Gupton | 12.08–12.22 | | Matthias Klages |
| Supervisory Special Agent Matthew "Matt" Simmons... | Daniel Henney | 13.01–15.10 | 10.19, 12.13 | Florian Hoffmann |
| Haley Hotchner, née Brooks. | Meredith Monroe | | 1.01–3.05, 5.01, 5.09–5.10, 9.05 | Schaukje Könning |
| Dr. Diana Reid | Jane Lynch | | 1.22–2.01, 2.15, 4.06–4.07, 12.11, 12.20, 12.22, 15.02, 15.10 | Marina Krogull (until season 12) Heike Schroetter (season 15) |
| Detective William "Will" LaMontagne, Jr. | Josh Stewart | | 2.18–5.10, 7.07–9.14, 11.22–15.10 | Sven Hasper |
| Section Chief Erin Strauss | Jayne Atkinson | | 2.23–3.06, 5.05–8.24, 9.14, 15.10 | Barbara Schnitzler |
| Jack Hotchner | Cade Owens | | 3.02–11.22 | Julian Kohler |
| Technical Analyst Kevin Lynch | Nicholas Brendon | | 3.09–10.02 | Stefan Krause |
| Supervisory Special Agent Jordan Todd | Meta Golding | | 4.05–4.13 | Claudia Urbschat-Mingues |
| Beth Clemmons | Bellamy Young | | 7.10–8.23 | Giuliana Jakobeit |
| Dr. Savannah Morgan, née Hayes... | Rochelle Aytes | | 9.08–11.18 | Antje von der Ahe |
| Section Chief Mateo "Matt" Cruz | Esai Morales | | 9.04–10.19 | Marcus Off |
| Joy Rossi, Former Struthers | Amber Stevens West | | 10.09–11.07, 14.15 | Julia Meynen |
| Kristy Simmons | Kelly Frye | | 13.03–15.10 | Heike Beeck |
| Krystall Richards | Gail O'Grady | | 13.18–15.10 | Karin Greger |
Personnel decisions
Lola Glaudini
At the beginning of the second season, Lola Glaudini left the series. In a statement, it was said that Glaudini was not comfortable with the Los Angeles location and would be moving back to the East Coast of the US for personal reasons.
Mandy Patinkin
Shortly before filming began on the third season, Mandy Patinkin unexpectedly left the series in 2007. Five years later, he commented as follows: "The biggest public mistake I ever made was taking (the job of) 'Criminal Minds' in the first place. I thought it was going to be something different. I never thought they would kill and rape all these women every day, every night, every week, year after year. It did my soul and my personality no good." Continuing, he said that he did not condemn the taste of the viewers but was concerned about the effect as all over the world the show was being used as a bedtime story.
A. J. Cook
At the beginning of the sixth season, A. J. Cook's contract was not renewed due to cost-cutting measures by the network CBS, as a leading actress was to leave. However, after a multitude of fan protests, CBS presented Cook with a contract again for the seventh season, which she signed. She has since rejoined the series' regular cast.
Paget Brewster
Along with Cook's contract cancellation, it was announced that Paget Brewster would also not be seen in all episodes of season six. Through negotiations, she was able to join a pilot episode of the network NBC. However, since the pilot did not go to series, CBS was able to bring Brewster back to the series because of a contract clause, so she was once again a full-fledged member of the main cast in the seventh season. However, in February 2012, she let it be known that "After six wonderful years as Emily Prentiss", she had decided to "seek a new challenge". She also wanted to take time off to work on other projects during filming, but the network and production studio would not allow it. After her exit, she made two more guest appearances on the series. At the beginning of the twelfth season, she was initially only supposed to return to the series for a longer story arc. However, as a result of Thomas Gibson's departure, Brewster was reinstated to the regular main cast.
Rachel Nichols
Rachel Nichols had joined the series as a replacement for Cook and Brewster during the sixth season. After the end of that season, her role was written out of the series. She did not learn this personally, but via a public service announcement from the network.
Jeanne Tripplehorn
Jeanne Tripplehorn joined the series as Paget Brewster's replacement in season eight. With the ninth season finale, she left the series without prior notice, as she did not renew her contract. She and producer Erica Messer had previously agreed to end her storyline. However, Tripplehorn was positive about her role, saying that the role came at just the right time for her, as she had wanted to embody a slightly "darker" role.
Jennifer Love Hewitt
Jennifer Love Hewitt joined the series as Tripplehorn's replacement. The actress became pregnant during the filming of the tenth season, which was also transferred to her role. The actress left the series on her own accord because she "want[ed] to give her second baby the same attention as her first, and that means taking time off and being a full-time mom." However, a return to the series would be open to her at any time.
Shemar Moore
Towards the end of the eleventh season, Shemar Moore surprisingly expressed his wish to leave the series, as he wanted to devote more time to his private life and new projects. The desire of the actor was transferred to his role, just as with Hewitt.
Adam Rodriguez
Adam Rodriguez, of CSI: Miami fame, has been signed on to replace the departed Shemar Moore.
Thomas Gibson
In August 2016, Thomas Gibson was summarily fired after allegedly kicking Virgil Williams, one of the show's co-executive producers, in an altercation.
Damon Gupton
In June 2017, it was announced that Damon Gupton would not be returning for the upcoming 13th season.
Daniel Henney
In June 2017, it was announced that Daniel Henney from Criminal Minds: Beyond Borders would join the regular cast of Criminal Minds in his role as Special Agent Matt Simmons starting in season 13 after its cancellation.