Manuel Serifo Nhamadjo (25 March 1958 – 17 March 2020) was a Guinea-Bissauan politician. He was the acting President of Guinea-Bissau from May 2012 to June 2014. His predecessor was Mamadu Ture Kuruma.
Nhamadjo died on 17 March 2020 in Lisbon, Portugal at the age of 61.