Whitmire is a town in Newberry County, South Carolina, United States. It is located along the Enoree River. The population was 1,441 at the 2010 census.

Whitmire is located at 34°30′8″N 81°36′51″W / 34.50222°N 81.61417°W / 34.50222; -81.61417 (34.502227, -81.614162).