Multiple organ dysfunction syndrome (MODS), previously known as multiple organ failure (MOF), Total organ failure(TOF) or multisystem organ failure (MSOF), is when the organ function is acutely ill and the patient is required medical intervention to achieve homeostasis. It usually involves two or more organ systems.
The use of "multiple organ failure" or "multisystem organ failure" should be avoided since that phrase was based upon physiological parameters to determine whether or not a particular organ was failing.