Schizophrenia

Schizophrenia or schizophrenic psychosis is the term used to describe mental illnesses with similar symptom patterns that belong to the group of psychoses.

In the acute stage of the disease, schizophrenic people experience a variety of characteristic disorders that affect almost all areas of internal experience and behavior, such as perception, thinking, emotional and mental life, volition, psychomotor activity and drive.

Often voices that are not really there are heard (so-called voice hearing). There may be delusions of being followed, spied on or controlled. Furthermore, the feeling of being controlled by others may occur, e.g. through thought withdrawal or thought inspiration. Persistent hallucinations of any sensory modality are possible. Social withdrawal, lack of drive, lack of motivation, emotional flattening and joylessness are also not infrequently observed. Depending on the predominant symptoms, several subgroups of schizophrenia are distinguished.

Schizophrenia is often mistakenly associated with the idea of a "split personality" by medical laypersons, as the literal translation of the term (schizophrenia = "split soul") seems to suggest (see etymology).

In most geographic cultures studied to date, approximately 0.5% to 1% of the population develops schizophrenia at least once during their lifetime. The risk of developing the disease is the same for men and women, although statistically men are affected at a slightly earlier age. Although schizophrenia has been described since ancient times, no single cause has been identified. It is therefore assumed today (as of 2021) that there is an interplay of several triggering factors.

In many cases, the symptoms disappear after the initial phase of the disease. After that, further phases of the disease (relapses) may follow at irregular intervals. In about one third of the patients, all symptoms disappear completely at some point. In about another third, recurrences occur again and again. In the last third, a chronic course results, which leads to a permanent mental disability.

There is a whole range of treatment options that often enable patients to lead a largely symptom-free life. The focus is on drug therapy with neuroleptics.

Artistic representation of a hallucination typical for schizophreniaZoom
Artistic representation of a hallucination typical for schizophrenia

Etymology and word history

The term schizophrenia is derived from the ancient Greek σχίζειν s'chizein = "to cleave, split, splinter" and φρήν phrēn = "spirit, soul, mind, diaphragm". In ancient Greece, the diaphragm was thought to be the seat of the soul, which is why the word "phren" (φρήν) stood for both terms. Until the middle of the 20th century, schizophrenia was literally translated as schizophrenia. This was intended to describe what was then regarded as the core of the illness: the "loss of the inner coherence of the processes of the soul".

The term was first introduced publicly by the Swiss psychiatrist Eugen Bleuler at a meeting of the German Psychiatric Association (DVP) in Berlin on April 24, 1908. Bleuler's colleague Carl Gustav Jung also used the term three days later on April 27 in Salzburg at the first International Psychoanalytic Congress (C.G. Jung was president of the congresses from 1910 to 1914). In the same year Bleuler published the article The Prognosis of Dementia praecox (Schizophrenia Group) in the Allgemeine Zeitschrift für Psychiatrie und psychischgerichtliche Medizin and in 1911 the well-known paper Dementia praecox or the Schizophrenia Group. Bleuler's concept of schizophrenia competed with Emil Kraepelin's concept of dementia praecox (premature dementia).

However, the first diagnoses with the designation "schizophrenia" were not made until 1921 and more frequently from 1930 onwards, at Burghölzli, (Eugen Bleuler had been director since 1898) for the first time in 1912.

In everyday clinical practice in psychiatric institutions, the term "Bleuler's disease" used to be used during ward rounds and in doctors' letters in order to avoid the negative and stigmatising term schizophrenia. In the past, schizophrenia and affective psychosis were combined under the term endogenous psychosis.

Schizophrenia is associated with limitations in some intellectual abilities, but not with reduced intelligence, although the historical term dementia praecox seems to reinforce this misconception. It is a matter of scientific debate whether schizophrenia is a single disease entity or a group of diseases - with different causes and courses.

Use of terms outside the technical language

Schizophrenia is often confused by medical laymen with identity disorders (dissociative identity disorder), especially with the idea of a "split personality". This is caused by a too literal back-translation of the two parts of the technical term, namely "split" and "mind".

In addition, since the 1950s, "schizophrenic" became established in colloquial language as a pejorative classification in the sense of "nonsensical, behaving absurdly, delusional, ambivalent". The general term mental illness was also formerly used for schizophrenia.

Symptoms

Main article: Symptoms and diagnosis of schizophrenia

The symptoms of schizophrenia are traditionally divided into two broad areas: Positive symptoms and Negative symptoms. More recently, however, the cognitive symptoms of the disorder have also received increasing attention and are seen as a separate third domain.

Contrary to what the term suggests, however, it does not refer to intelligence deficits, but to problems with attention, memory, and action planning, among other things. The extent to which these areas are affected best predicts how well patients can cope with everyday life. Cognitive disturbances of this type are a central symptom complex of schizophrenia. Thinking may become short-tempered, or multi-layered relationships may not be grasped in their complexity. Linguistic expression becomes impoverished. In exacerbated cases, perseveration (stereotyped repetition of a word or thought) or idiolalia (unintelligible sounds) may occur.

The severity of symptoms depends in part on the personality of the individual. The overall symptomatology differs greatly between different individuals; however, individual patients often retain their individual symptom pattern over long periods of time.

Positive symptoms

Positive symptoms (or plus symptoms) denote exaggerations of normal experience and are therefore regarded as a kind of "surplus" compared to the healthy state. These include strong misconceptions of the experienced reality up to hallucinations and loss of reality. Schizophrenias with predominantly positive symptoms often begin suddenly, and often there are no outwardly conspicuous features beforehand. The course of the disease is rather favourable in this case.

Characteristic positive symptoms are content-related thought disorders, ego disorders, sensory delusions and inner restlessness. Typical for the content-related thought disorders is the formation of a delusion. Auditory hallucinations (acoasms) are common: About 84% of people with schizophrenic psychosis perceive thoughts that they think their origin is external. For example, they perceive voices that, in rare cases, also give orders. This is referred to in common parlance as "hearing voices". Often those affected have the impression of being insulted by foreign voices. Such an experience may occur while alone or in the midst of sentences said by bystanders. Hallucination of voices also occurs in deaf people, even in those born deaf. However, in deaf persons with a diagnosis of schizophrenia, visual and tactile hallucinations are significantly more common (in about 50% of persons each) than in schizophrenia in general (about 15% and 5%, respectively).

Ego disorders include:

  • Ideation: experiencing one's own thoughts as imposed by others
  • Thought propagation: the idea that others could "eavesdrop" or "read" one's own thoughts
  • Thought deprivation: sense of loss that others are stealing or cutting off one's thoughts.
  • External control: Feeling of being controlled by others like a remote-controlled robot.

Negative symptoms

Negative symptoms (or minus symptoms) refer to limitations of normal experience as well as of mental functions that were previously present but are reduced or completely absent due to the disease. These symptoms thus represent a deficiency compared to the healthy state. The following table gives an overview of the negative symptoms:

Negative symptom

Explanation

Affect flattening

Lack of range of emotions in perception, experience and expression. The impoverishment of emotions (affects) manifests itself in a reduced ability to "participate emotionally". The affected persons react emotionally only to a limited extent to normally moving events and appear to be little touched by pleasant or unpleasant events. The normal change between different affective states (joy, curiosity, sadness, anger, pride ...) is lost.

Alogie

Lack of verbal expression with delayed, wordy responses and poorly differentiated language.

Asociality

lack of sociability in the form of disinterest in socialising with others, social withdrawal, few friends and little sexual interest (not to be confused with anti-social behaviour)

Avolition

lack of ability to initiate and maintain goal-directed behaviour

Drive disorder

reduced ability and will for goal-oriented activity (lack of drive)

Abulie

Lack of willpower in the form of difficulty in making decisions

Apathy

lack of excitability and insensitivity to external stimuli, leading to apathy and lack of interest

Anhedonia

lack of capacity to feel pleasure or enjoyment

"dynamic draining"

Lack of motivation for activities with resulting lack of drive. Includes lack of future planning, up to extensive lack of perspective.

motor deficits

Lack of facial expression and gestures with reduced movement. These deficits often make the ill person appear aloof or out of touch. This distance can be bridged by attention, which is usually gratefully accepted by the ill person, even if they cannot show this through facial expressions and gestures. The impoverishment of psychomotor activity makes affective resonance appear more impaired than it is. Thus, if patients are not spoken to during a solidified delusional state, they are usually receptive to attention.

Schizophrenia with pronounced negative symptoms often begins insidiously, and the course of the disease is rather unfavorable. Negative symptoms can occur months or years before the acute psychotic symptoms ("bend in the life curve", "preceding defect"). Very often, sleep disturbances and not infrequently depressive symptoms occur as early symptoms. The negative symptoms usually intensify or solidify with increasing duration of the illness.

In about two thirds of people suffering from schizophrenia, the negative symptoms outlast the positive symptoms after an acute episode ("schizophrenic defect", "residual state", "residual symptomatology"). These limitations, which vary in severity, lead to contact disorder, social withdrawal, and often disability. However, in a certain percentage of people with schizophrenia, no residual symptoms remain (see residual symptomatology).

After the acute phase of a relapsing schizophrenia has subsided, a temporary depressive episode ("depressive aftershock") occasionally follows. A distinction should be made between true negative symptoms and the side effects of therapy with a neuroleptic. The side effects of neuroleptics can be similar to negative symptoms.

Questions and Answers

Q: What is schizophrenia?


A: Schizophrenia is a mental illness where people may see, hear or believe things that are not real. It can be a big problem for people who have it.

Q: How common is schizophrenia?


A: Schizophrenia is relatively common, affecting one in 200 people.

Q: Is schizophrenia contagious?


A: No, schizophrenia is not infectious in any way.

Q: What are the signs of schizophrenia?


A: Some common signs of schizophrenia include strange beliefs, unclear or confused thinking and language, hallucinations (such as hearing voices that aren't there), poor interaction with others, less expression of feelings, and not doing much. They also may not care about many things.

Q: When does schizophrenia usually first appear?


A: Very often it first appears in teenage years when the sufferer goes through puberty.

Q: Is there a cure for schizophrenia?



A: As of 2021, there is no cure for schizophrenia but a combination of therapy and certain drugs can allow most people suffering from it to lead a normal life.

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