São Vicente is an island of Cape Verde. It is in the Barlavento Islands group. São Vicente was discovered by the Portuguese discoverer Diogo Afonso on 22 January 1462.

92% of the island population lives in the urban area of Mindelo. It is on the Porto Grande Bay. Mindelo is the capital city of the municipality.

São Vicente has a hot and dry climate. The average annual temperature in Mindelo is 23.6 °C (74 °F).