What is protein folding?
Q: What is protein folding?
A: Protein folding is the process of a polypeptide chain transforming from an unfolded linear chain of amino acids into its characteristic three-dimensional shape.
Q: What holds the structure together?
A: The structure of a folded protein is held together by hydrogen bonds.
Q: What are the stages of protein folding?
A: The stages of protein folding include an unfolded polypeptide or random coil when translated from mRNA to a linear chain of amino acids, and then interacting with each other to produce a well-defined three-dimensional structure, known as the native state.
Q: What happens if proteins do not fold correctly?
A: If proteins do not fold into their native shape, they are inactive and usually toxic. This can lead to several diseases and allergies caused by misfolded proteins that the immune system does not recognize.
Q: Who solved the protein folding problem in 2020?
A: On 30 November 2020, the protein folding was solved by artificial intelligence company DeepMind.
Q: What is Anfinsen's dogma? A: Anfinsen's dogma states that the resulting three-dimensional structure of a folded protein is determined by its amino acid sequence.
