What are progeroid syndromes (PS)?
Q: What are progeroid syndromes (PS)?
A: Progeroid syndromes are a range of genetic disorders where the affected person appears to grow older faster.
Q: What causes PS?
A: Most known PS mutations lead to either defects in the DNA repair mechanism, or defects in a protein known as lamin A/C.
Q: What does progeroid mean?
A: Progeroid means resembling old age.
Q: Can Alzheimer's and Parkinson's diseases be considered as progeroid syndromes?
A: No, Alzheimer's and Parkinson's diseases only affect one tissue, and the term progeroid syndrome is used for cases where the affected people only show some of the features of aging, but not all of them.
Q: How many different types of tissues can be affected in progeroid syndromes?
A: In progeroid syndromes, many different kinds of tissue are affected.
Q: What is the lifespan of individuals with PS-related disorders?
A: Individuals with PS-related disorders often have a reduced lifespan.
Q: What are the most widely studied progeroid syndromes, and why?
A: The most widely studied progeroid syndromes are Werner syndrome (WS) and Hutchinson-Gilford Progeria Syndrome (HGPS), because they resemble natural aging.
