Whether the constants of nature are also really constant over astronomical time periods is the subject of current research. For example, measurements of the spectral lines of quasars with the Keck telescope in Hawaii seemed to indicate a slight decrease in the fine structure constant by about one hundredth of a part per thousand over the course of ten billion years. This result was controversial from the beginning; on the one hand, researchers pointed out the uncertain error estimate of the data analysis, and on the other hand, there are data from the Oklo mine in West Africa, where about 2 billion years ago uranium had accumulated to such an extent and had such a high content of the isotope U-235 that a nuclear fission chain reaction took place. According to these data, the fine structure constant had the same numerical value then as it does today. Recent measurements of the spectral lines of quasars with the Very Large Telescope of the European Southern Observatory in Chile contradict the earlier results at the Keck telescope and point to the constancy of the fine structure constant.
In the meantime, precision measurements are possible that can verify any steady fluctuations of the order of magnitude suggested by the observations with the Keck telescope, even in the laboratory over short periods of time. Investigations by Theodor Hänsch and his research group at the Max Planck Institute of Quantum Optics prove the constancy of the fine structure constant with an accuracy of 15 decimal places over a period of four years.