What does autophagy mean?

Q: What does autophagy mean?


A: Autophagy means "eating itself".

Q: What is the purpose of autophagy?


A: The purpose of autophagy is to allow the controlled breaking down of cell parts which do not work, or are not needed.

Q: How are cell parts broken down through autophagy?


A: Targeted cell parts may be isolated from the rest of the cell in an autophagosome, which fuses with lysosomes and the contents are broken down and recycled.

Q: In what extreme case does the breakdown of cellular components promote cellular survival?


A: In the extreme case of starvation, the breakdown of cellular components promotes cellular survival by maintaining cellular energy levels.

Q: Who coined the term "autophagy" and when?


A: Belgian biochemist Christian de Duve coined the term "autophagy" in 1963.

Q: When were autophagy-related genes identified in yeast?


A: Autophagy-related genes in yeast were identified in the 1990s.

Q: Who was awarded the 2016 Nobel Prize in Physiology or Medicine for their work on autophagy?


A: Japanese researcher Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his work on autophagy.

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