Messier 100 (also known as NGC 4321) is an example of a so-called 'grand design' spiral galaxy. It is visible in the southern part of constellation Coma Berenices. Messier 100 is one of the brightest and largest galaxies in the Virgo cluster, about 55 million light-years away, with a diameter of 160,000 light years. It was discovered by Pierre Méchain in 1781. Later it was entered in Messier’s catalogue of nebulae and star clusters after Charles Messier made observations of his own a month later. The galaxy was one of the first spirals discovered, and was listed as one of 14 spiral nebulae by the Earl of Rosse in 1850.

The galaxy has two satellite galaxies, NGC 4323 – connected with M100 by a bridge of luminous matter – and NGC 4328.