Mandello del Lario is an Italian town and comune in the province of Lecco, in Lombardy. It is on Lake Como.

Since 1921, Mandello del Lario has been home to the Italian motorcycle maker Moto Guzzi. Guzzi is owned by Piaggio & Co. SpA. Each year since 2001, the commune has hosted GMG (aka Giornata Mondiale Guzzi or Worldwide Guzzi Days).

The Grigna massif is in Mandello's territory.