The arrondissement of Vouziers is an arrondissement of France in the Ardennes department in the Grand Est region. Its capital is the city of Vouziers.

It is in the southeast of the department with an area of 1,412.2 square kilometres (545.3 square miles), the second largest arrondissement of the department, but the one with fewest people living in it with 22,050 inhabitants and a density of 15.6 inhabitants/km².