The arrondissement of Charleville-Mézières is an arrondissement of France in the Ardennes department in the Grand Est region. Its capital is the city of Charleville-Mézières.

It is the most northern of the arrondissements of the department. It has an area of 1,825.3 km2 (704.8 sq mi), the largest arrondissement of the department. It is the arrondissement with more people living in it, with 160,939 inhabitants and a density of 88.2 inhabitants/km².