Jefferson Station is a SEPTA station in the Market East neighborhood of Philadelphia, Pennsylvania. Its official SEPTA address is 12th and Filbert streets. Of the three Center City stations on the SEPTA system, Jefferson Station is located the farthest east. It is part of the Center City Commuter Connection. Opened in November 1984, the station replaced the Reading Terminal, which had closed on November 6, 1984. Jefferson Station cost $75 million to build, and is owned and maintained by SEPTA. The station used to be called Market East Station but the name changed to Jefferson Station on September 4, 2014 after Thomas Jefferson University Hospital paid $4 million to have the station named for them.

The station is 120 feet (37 m) wide and two blocks long. The tracks are 35 feet (11 m) below the street.