Coordinates: 23°38′S 70°24′W / 23.633°S 70.400°W / -23.633; -70.400

The II Antofagasta Region (Spanish: II Región de Antofagasta) is one of Chile's 15 first order administrative divisions. It is the second-largest region of Chile. To the east it borders Bolivia and Argentina.

The capital of the region is the port city of Antofagasta.