The Holy See (Latin: Sancta Sedes, "holy seat") is the office of the Bishop of Rome, that is, the Pope. The term Holy See also means the Pope and the Roman Curia, the central government of the Roman Catholic Church.

Every episcopal see is seen as holy and the Eastern Orthodox Church constantly applies the adjective "holy" or "sacred" (ἱερά) to all its sees, but "the Holy See" (definite singular) normally means the see of Rome, which is also called "the Apostolic See". While "Apostolic See" can refer to any see founded by any of the Apostles, the term is in this case used to refer to the see of the bishop seen as successor of the chief of the Apostles, Saint Peter.

Aside from Rome, the archiepiscopal See of Mainz, which was also of electoral and primatial rank, is the only other Western see that bears the title of "Holy See", although this usage is less common.