Ghanzi (sometimes Gantsi) is a district in western Botswana. The capital city is also named Ghanzi.

Most of the eastern half of Ghanzi is the Central Kalahari Game Reserve. Deception Valley, Ghanzi Craft, and Khutse Game Reserve are other major tourist attractions.

Ghanzi is divided into Charles Hill Sub-District and Ghanzi Sub-District.