Garhi Yasin is a town and taluka in the north of Sindh province of Pakistan. It is the second largest town in the Shikarpur District. It is also one of the four divisions of the districts. The town has a population of more than 14,000. Garhi Yasin is on the right bank of River Indus. The area has always been important as a part of the trade route through the Bolan Pass.

The town is named after its founder, Yasin Khan Pathan. Sindhi is the common language of the people in this region. The population of the town includes members of many different tribes. These tribes include the Pathan,mangi, Memon, Soomra, Shaikh, Syed, Mirani, Qazi, Bhutta, Abra, Channa, Lashari, Bhatti, Dinari, Mahar, Kakepota, Brohi and others. Beside a large number of Hindu, Punjabi and some Muhajirs (from India) also live in the town. The people live here without any discrimination of caste, color, language and religion.