What is the fixed-dose procedure (FDP)?
Q: What is the fixed-dose procedure (FDP)?
A: The fixed-dose procedure (FDP) is a method proposed in 1984 that tests a substance's acute oral toxicity using fewer animals with less suffering than the older LD50 test.
Q: What was the LD50 test?
A: The LD50 test is a test that was developed in 1927 and uses 60-80 animals to find a dose that kills 50% of animals in a given time.
Q: How many animals does FDP use?
A: FDP uses 10-20 animals to find the dose that produces toxicity signs but not death, and from there predicts the lethal dose.
Q: How does FDP predict the lethal dose?
A: FDP uses the dose that produces toxicity signs but not death to predict the lethal dose.
Q: When does FDP sometimes need retesting?
A: FDP sometimes needs retesting using slightly higher or lower doses.
Q: Why was FDP proposed?
A: FDP was proposed to test a substance's acute oral toxicity using fewer animals with less suffering than the older LD50 test.
Q: How does FDP reduce animal suffering?
A: FDP reduces animal suffering by using fewer animals and finding a dose that produces toxicity signs but not death.
