First Nations (French Premières Nations, German Erste Nationen) refers to all indigenous peoples in Canada except the Métis (descendants of Cree and Europeans) and the Inuit living in the north. If these are also to be included, the terms First Peoples and Premiers Peuples (First Nations) or Aboriginal Peoples and Peuples aborigènes (aboriginal peoples) are sometimes used; in recent years, the terms Autochthon Peoples and Peuples autochtones have been used more frequently in both of Canada's main languages.

Often, the term First Nations is not used to refer to an ethnic group, but rather to a political group, which sometimes leads to the term referring to the government of the respective ethnic group. It is also occasionally used to refer to individuals - in the form First Nations People - but the term Indian is much more common here, even if it is controversial.

The term First Nations probably first appeared in the early 1980s. This created a term that differs significantly from the term Indian Tribe or Band, which is also used in Canada. However, this applies less to everyday usage than to the legal and political spheres. A nation can invoke international law, often referred to as "international law"; an ethnic group can only invoke minority protections.

Of the approximately 700,000 people who consider themselves Indians, about 565,000 belong to the 617 tribes recognized by the state (as of the beginning of 2014), of which almost 200 live in British Columbia alone. Only they are legally considered Indians in the sense of the responsible ministry, the Department of Indigenous and Northern Affairs. About 133,000 do not belong to a tribe, so they are First Nations, and yet they are not Indians in the legal sense. The state thus determines whether a group constitutes a tribe and whether a member of a First Nation is an Indian. The concept of First Nations counters this power of definition with the right of aboriginal peoples to determine. Moreover, government usage outside the legal sphere is imprecise. In German, the term "Indianer" is likewise not unencumbered (see Indian image in the German-speaking world), yet it will be used here for reasons of understanding.

More recently, Native Americans in the U.S., referred to as American Indians or Native Americans, in Alaska as Alaska Natives, sometimes as Locals, are referred to as First Americans by analogy with First Nations.