Overview

Endometriosis is a chronic medical condition characterized by the presence of tissue resembling the endometrium — the inner lining of the uterus — in locations outside the uterus. These misplaced growths are made of cells similar to those of the uterine lining, and are often called implants, lesions, endometriomas (when forming cysts on the ovaries) or adhesions when they cause scarring. The condition primarily affects people assigned female at birth and is most frequently diagnosed in reproductive years, although symptoms can appear at any age. Epidemiological estimates vary; studies suggest that a substantial minority of people of reproductive age have endometriosis, with some surveys indicating prevalence around one in ten in certain populations.

Typical signs and symptoms

Symptoms range from mild to severe and may include pelvic pain, painful periods (dysmenorrhea), pain with intercourse (dyspareunia), heavy or irregular menstrual bleeding, fatigue, and bowel or bladder symptoms during menses. Endometriosis is also associated with infertility: it can interfere with ovulation, fallopian tube function, and the pelvic environment necessary for conception. Symptom severity does not always match disease extent; small implants can cause intense pain while larger deposits may be asymptomatic.

Causes and theories

The exact cause of endometriosis is unknown. Several theories exist and may act together in different people. Retrograde menstruation — the backward flow of menstrual fluid through the fallopian tubes into the pelvic cavity — is a commonly cited mechanism that could deposit endometrial cells outside the uterus. Other hypotheses include coelomic metaplasia (transformation of pelvic lining cells into endometrial-like cells), immune system dysfunction that allows ectopic tissue to implant and persist, and genetic or hormonal factors that increase susceptibility. Research continues to investigate molecular pathways and inherited risks.

Diagnosis

Because symptoms can mimic other conditions and vary widely, diagnosis often requires a combination of clinical assessment and imaging. A pelvic examination may reveal nodules or tenderness, but many cases are not detectable on exam. Imaging studies such as ultrasound and MRI can help identify ovarian endometriomas and suggest deep infiltrating disease, but they do not detect all forms. Definitive diagnosis historically relies on direct visualization of lesions and histologic confirmation obtained through laparoscopy with biopsy. Clinicians increasingly use symptom patterns and imaging to guide treatment without surgical confirmation when appropriate.

Treatment and management

Treatment focuses on symptom relief, preservation or restoration of fertility when desired, and reducing lesion progression. Medical options aim to suppress ovarian hormone production or alter the hormonal environment that fuels lesion activity. These include analgesics for pain, hormonal contraceptives such as combined oral birth control, progestins, and hormonal modulators including GnRH agonists or antagonists. Medical therapy often reduces pain and slows lesion growth but may not be curative; symptoms can recur after stopping medication.

  • Surgical management ranges from conservative laparoscopy — excision or ablation of implants and removal of endometriomas — to more radical procedures for severe disease. Surgery can relieve pain and improve fertility outcomes in selected patients.
  • For infertility related to endometriosis, options include fertility-preserving surgery, ovulation induction, intrauterine insemination, and assisted reproductive technologies such as in vitro fertilization.
  • Long-term care frequently combines medical, surgical, and supportive measures (pain management, physical therapy, and psychological support) to address quality of life.

Impact and notable points

Endometriosis can have profound effects on quality of life, work productivity, relationships, and mental health. Because it may be underdiagnosed and symptoms can be normalized as "bad periods," delays in diagnosis are common. Management is individualized: some people achieve symptom control with medical therapy, others require surgery, and some need both approaches over time. While treatments can reduce symptoms and improve fertility outcomes, there is currently no universally accepted cure; recurrence can occur.

Research directions and distinctions

Active research seeks better noninvasive diagnostic tests, targeted medical therapies that address underlying molecular drivers, and strategies to prevent recurrence. Distinctions within the condition—superficial peritoneal implants, ovarian endometriomas, and deep infiltrating endometriosis—help guide treatment decisions because they differ in location, symptom profile, and response to therapy.

For more information on the uterine lining and related terminology see cells, and for resources on diagnosis and treatment options consult clinical guidelines and specialist centers. Awareness, timely evaluation, and individualized care remain central to improving outcomes for people affected by endometriosis.