In cell biology, the centrosome is an organelle that is the main place where cell microtubules are organized. Also, it regulates the cell division cycle, the stages which lead up to one cell dividing in two.

The centrosome was discovered by Edouard Van Beneden in 1883, and was described and named in 1888 by Theodor Boveri.

The centrosome has apparently only evolved in animal cells. Fungi and plants use other structures to organize their microtubules. Although the centrosome has a key role in efficient mitosis in animal cells, it is not necessary.

A centrosome is composed of two centrioles at right angles to each another. They are surrounded by a shapeless mass of protein.