The 1980 Quebec independence referendum was the first referendum in Quebec on whether Quebec should make a deal with Canada that would allow the province to have more control over its own laws, government, and trade agreements with other countries. The referendum was called by Quebec's Parti Québécois (PQ) government. The PQ wanted Quebec to be independent from Canada.

The province-wide referendum took place on Tuesday, May 20, 1980, and the proposal to request more independence from Canada was defeated. 59.56 percent of voters voted against the referendum question and 40.44 percent voted in favour of it.

A second referendum on sovereignty in 1995 also failed, but by a smaller margin (50.58% to 49.42%).