Vendôme is a commune in central French, and is a subprefecture in the Loir-et-Cher department. It is also the capital of the arrrondissement of Vendôme and the administrative centre of the Vendôme canton.

Vendôme is one of the main towns along the Loir river. It is the third largest city of the department after Blois and Romorantin-Lanthenay.