Ústí nad Labem Region or Ústecký Region is an administrative unit (kraj) of the Czech Republic. The capital city is Ústí nad Labem.

The area along the German border has the Ore Mountains and Lužice Mountains. The Elbe River is the largest watercourse in the region. Other main rivers in the region include Ohře, Bílina, Ploučnice and Kamenice.